Microsoft have released EMET 5.0 details here. I've been running EMET for quite some time now, it's very unobtrusive and fairly intuitive.  It can also be integrated to good effect with the MS System Center suite. If you're running Windows, install it and make a bad guy's life that little bit harder.

This is a nice rundown on Microsoft EMET's functionality and its strengths and weaknesses.  I've been running EMET for about 6 months, its very unobtrusive and I'm yet to see it cause an issue with the applications that I run. I believe the more recent versions are also able to be managed with MS System Center for larger environments.